Partners in Repression

The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression.

The extra sex combs (esc) and Enhancer of zeste [E(z)] proteins are members of the Drosophila Polycomb group (Pc-G) of transcriptional repressors. Here we present evidence for direct physical interaction between the esc and E(z) proteins using yeast two-hybrid and in vitro binding assays. In addition, coimmunoprecipitation from embryo extracts demonstrates association of esc and E(z) in vivo. W...

Financial Depth – Financial Repression Linkage

Financial Repression, Economic Growth and Development

Economic growth and development of market, stock exchange and related variables are among components which influence on business, economic activities and management of society. Financial repression is among economic variables greatly influencing on financial market specifically capital market and economic growth and development; so that, this concept caused to publish financial growth and devel...

Repression-free utrophin-A 5’UTR variants

Mutation in the dystrophin gene results Duchenne Muscular Dystrophy (DMD), an X-linked fatal neuromuscular disorder. Dystrophin deficiency can be compensated by upregulation of utrophin, an autosomal homologue of dystrophin. But the expression of utrophin in adults is restricted to myotendinous and neuromuscular junctions. Therefore utrophin upregulation throughout the muscle fiber can only be ...

Partners in kinesin activation

Partners in kinesin activation I t takes two to turn on a kinesin, say Blasius et al. on page 11. Kinesin-1 motoring on microtubules requires cargo plus a second binding partner to relieve the motor of its inhibited conformation. On its own, Kinesin-1 is an inactive motor. Inhibition of the solitary motor probably ensures that it is not needlessly burning ATP or clogging up the microtubule road...